PXD063690
PXD063690 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Novel Strategy to Rapidly Profile and Quantify High-Risk Host Cell Proteins using Integrated DDA-PRM-dMRM Mode |
| Description | We developed a novel strategy using integrated DDA-PRM-dMRM to comprehensively profile and quantify high-risk HCPs in CHO cell-derived biotherapeutics. Firstly, we performed deep proteomic analysis of CHO cells using DDA-PASEF mode, constructing a high-quality spectral library covering all potential HCPs. Based on the constructed library, we validated the target list using PRM-PASEF and MRM modes. |
| HostingRepository | iProX |
| AnnounceDate | 2025-05-03 |
| AnnouncementXML | Submission_2025-05-06_20:03:35.445.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xuan Xu |
| SpeciesList | scientific name: Cricetulus griseus; NCBI TaxID: 10029; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro; 6490 Triple Quadrupole LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-06 20:02:48 | ID requested | |
| ⏵ 1 | 2025-05-06 20:03:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Host cell proteins |
| LC-MS/MS |
| Biotherapeutic impurities |
| Chinese hamster ovary cell |
| Proteomics |
Contact List
| Jinlan Zhang | |
|---|---|
| contact affiliation | Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Materia Medica |
| contact email | zhjl@imm.ac.cn |
| lab head | |
| Xuan Xu | |
| contact affiliation | Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Materia Medica |
| contact email | xuxuan@imm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
