PXD063663

PXD063663 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Specificity profiling of SARS-CoV-2 PLpro using proteome-derived libraries of linear peptides suggests secondary preference for basic motifs
Description	This deposit contains the primary datasets and code underlying our study "Specificity profiling of SARS-CoV-2 PLpro using proteome-derived peptide libraries suggests secondary preference for basic motifs." In this work, we combined proteome-derived Identification of Cleavage Sites (PICS) workflows, using both NHS-acetate and TMT labeling, with intact-lysate N-terminomics to map cleavage preferences of the SARS-CoV-2 papain-like protease (PLpro).
HostingRepository	MassIVE
AnnounceDate	2025-05-12
AnnouncementXML	Submission_2025-05-12_06:56:06.545.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Vogele
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Escherichia coli; common name: E. coli; NCBI TaxID: 562;
ModificationList	Acetyl; Label:2H(4)+Acetyl; TMT6plex
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-06 09:22:17	ID requested
⏵ 1	2025-05-12 06:56:06	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: SARS-CoV-2 Papain-Like Protease, Substrate Specificity, PICS (Proteomic Identification of Cleavage Sites), TMT Quantitative Proteomics, Dibasic Cleavage Motif, DatasetType:Proteomics

submitter keyword: SARS-CoV-2 Papain-Like Protease, Substrate Specificity, PICS (Proteomic Identification of Cleavage Sites), TMT Quantitative Proteomics, Dibasic Cleavage Motif, DatasetType:Proteomics

Contact List

Prof. Oliver Schilling
contact affiliation	Institute for Surgical Pathology, University Medical Center Freiburg
contact email	oliver.schilling@mol-med.uni-freiburg.de
lab head
Daniel Vogele
contact affiliation	Institute of Surgical Pathology, AG Schilling
contact email	daniel.vogele@uniklinik-freiburg.de
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097809/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097809/