⮝ Full datasets listing
PXD063614
PXD063614 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic characterization of infant and adult ornithine aminotransferase-deficient mice |
| Description | The deficiency of ornithine aminotransferase (OAT) cause gyrate atrophy, a progressive chorioretinal degeneration disease culminating in blindness. This project investigates age- and tissue-specific proteomic changes in the retina, retinal pigment epithelium (RPE), and liver of OAT-deficient mice to uncover the role of the enzyme in these tissues and the mechanisms underlying the eye damage. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-06 |
| AnnouncementXML | Submission_2026-07-05_17:35:59.216.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD063614 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Dennis Province |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-05 12:15:46 | ID requested | |
| ⏵ 1 | 2026-07-05 17:36:00 | announced |
Publication List
| 10.1016/j.exer.2026.111140; |
| Puja A, Xu R, Mascari I, Ngo T, Zhang Y, Wang Q, Saravanan M, Du J, Early proteomic and metabolic signatures of liver and eye in OAT-deficient mice. Exp Eye Res, 271():111140(2026) [pubmed] |
| 10.6019/PXD063614; |
Keyword List
| submitter keyword: ornithine, metabolism,ornithine aminotransferase, proteomics, gyrate atrophy, retina pigment epithelium, liver, OAT, retina |
Contact List
| Jianhai Du | |
|---|---|
| contact affiliation | Associate Professor, Department of Biochemistry and Molecular Medicine, West Virginia University |
| contact email | jianhai.du@wvumedicine.org |
| lab head | |
| Dennis Province | |
| contact affiliation | UAMS |
| contact email | dprovince@uams.edu |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD063614 |
| PRIDE project URI |
Repository Record List
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