PXD063586

PXD063586 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Amniotic fluid glycoproteins as potential ligands for macrophage galactose-type C-type lectin: implications for immunoregulation during pregnancy
Description	Immunity during pregnancy must be precisely balanced, because the mother's body needs to effectively fight pathogens while maintaining tolerance of the semi-allogeneic fetus. Factors that participate in achieving the proper immune balance during pregnancy include glycoproteins that expose sugar residues recognized by specific lectin receptors. Several types of lectins and their ligands has been detected at the maternal-fetal interface, and changes in their expression level have been correlated with pregnancy complications. Although the presence of potential sugar ligands for human macrophage galactose-type lectin (MGL), including LacdiNAc and (sialo)Tn antigen, has been detected in amniotic fluid, placenta and fetal tissues, the interaction between them and its possible role have not been elucidated so far. The aims of the experiment were to evaluate reactivity of MGL with amniotic fluid proteins and to isolate and identify the amniotic ligands of MGL.
HostingRepository	PRIDE
AnnounceDate	2025-10-01
AnnouncementXML	Submission_2025-10-01_01:45:40.502.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD063586
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Justyna Szczykutowicz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	complex glycosylation
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-04 09:40:12	ID requested
⏵ 1	2025-10-01 01:45:40	announced

Publication List

10.6019/PXD063586;
10.1038/S41598-025-16909-2;

10.6019/PXD063586;

10.1038/S41598-025-16909-2;

Keyword List

submitter keyword: MGL
CLEC10A
ligands
amniotic fluid

submitter keyword: MGL

CLEC10A

ligands

amniotic fluid

Contact List

Magdalena Orczyk-Pawiłowicz
contact affiliation	Wroclaw Medical University
contact email	magdalena.orczyk-pawilowicz@umw.edu.pl
lab head
Justyna Szczykutowicz
contact affiliation	Wroclaw Medical University
contact email	justyna.szczykutowicz@umw.edu.pl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD063586
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD063586

PRIDE project URI

Repository Record List

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