PXD063582

PXD063582 is an original dataset announced via ProteomeXchange.

Title	Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy
Description	Maladaptive changes in the function, expression and localization of proteins involved in calcium-handling worsen the impaired contractility of systolic heart failure (HF). Standard proteomics techniques require cell lysis and so are unable to characterize changes specific to the critical sub-cellular domain bounded by the T-tubule and the sarcoplasmic reticulum, known as the cardiac dyad. Traditional approaches are also less likely to capture low-affinity protein-protein interactions on lipid membranes. To improve our understanding of heart failure pathophysiology, we applied proximity proteomics to cardiac dyads of mice with ischemic cardiomyopathy.
HostingRepository	PRIDE
AnnounceDate	2026-04-15
AnnouncementXML	Submission_2026-04-15_15:56:41.257.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD063582
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Marian Kalocsay
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-03 23:25:15	ID requested
⏵ 1	2026-04-15 15:56:41	announced

10.6019/PXD063582;

10.1101/2025.05.08.652977;

submitter keyword: Gal-1 cardiac inotropy lusitropy proximity labeling

Jared Kushner
contact affiliation	Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA
contact email	jsk2018@cumc.columbia.edu
lab head
Marian Kalocsay
contact affiliation	The University of Texas MD Anderson Cancer Center Department of Experimental Radiation Oncology
contact email	mkalocsay@mdanderson.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063582

PRIDE project URI

• PRIDE
  1. PXD063582
     1. Label: PRIDE project
     2. Name: Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy