PXD063576 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantification of protein level changes under elevated mitochondrial abasic site damage |
| Description | The project aims to examine the protein level changes under induced mitochondrial abasic site lesions in HeLa cells using stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics. The data revealed significant changes in the expression level of several proteins. A decrease in mitochondrial ribosomal proteins (MRPS35, MRPL15, MRPL37, MRPL13, and MRPL4) and complex I subunits (NDUFA12 and NDUFA13) was observed, suggesting a suppression of mitochondrial protein synthesis and energy production under these conditions. In addition, the levels of ARF5 (ADP ribosylation factor 5), DNM1L (dynamin-1-like protein), and PRDX6 (peroxiredoxin 6) were upregulated. ARF5 is involved in protein trafficking, and DNM1L mediates mitochondrial and peroxisomal division. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-03 |
| AnnouncementXML | Submission_2025-12-03_15:20:39.543.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yu Hsuan Chen |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-03 10:33:13 | ID requested | |
| ⏵ 1 | 2025-12-03 15:20:40 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: mitochondrial DNA damage, mitochondrial DNA repair,abasic sites, mitochondrial DNA degradation |
Contact List
| Linlin Zhao |
|---|
| contact affiliation | Associate Professor of Chemistry, University of California, Riverside |
| contact email | linlin.zhao@ucr.edu |
| lab head | |
| Yu Hsuan Chen |
|---|
| contact affiliation | University of California, Riverside |
| contact email | ychen921@ucr.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063576 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063576
- Label: PRIDE project
- Name: Quantification of protein level changes under elevated mitochondrial abasic site damage
