PXD063461

PXD063461 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
Description	A substantial proportion of common variable immunodeficiency (CVID) patients has duodenal inflammation of largely unknown etiology. However, because of its histologic similarities with celiac disease, gluten sensitivity has been proposed as a potential mechanism. We aimed to elucidate the role of the duodenal microenvironment in the pathogenesis of duodenal inflammation in CVID by investigating the transcriptional, proteomic, and microbial signatures of duodenal biopsy samples in CVID.
HostingRepository	PRIDE
AnnounceDate	2025-04-29
AnnouncementXML	Submission_2025-04-29_13:20:39.721.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Animesh Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-29 12:30:26	ID requested
⏵ 1	2025-04-29 13:20:40	announced

Publication List

Kaarb, ø M, Yang M, Hov JR, Holm K, de Sousa MML, Macpherson ME, Reims HM, Kran AB, Halvorsen B, Karlsen TH, Aukrust P, Lundin KEA, Fevang B, Bj, ø, r, å, s M, J, ø, rgensen SF, Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses. J Allergy Clin Immunol, 151(3):767-777(2023) [pubmed]
10.1016/j.jaci.2022.09.029;

Kaarb, ø M, Yang M, Hov JR, Holm K, de Sousa MML, Macpherson ME, Reims HM, Kran AB, Halvorsen B, Karlsen TH, Aukrust P, Lundin KEA, Fevang B, Bj, ø, r, å, s M, J, ø, rgensen SF, Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses. J Allergy Clin Immunol, 151(3):767-777(2023) [pubmed]

10.1016/j.jaci.2022.09.029;

Keyword List

submitter keyword: microbiota,IgA,tract,disease,RNA,proteomics,gut,microbiome,duodenum,sequencing,gastrointestinal,celiac,CVID,Primary,immunodeficiency

submitter keyword: microbiota,IgA,tract,disease,RNA,proteomics,gut,microbiome,duodenum,sequencing,gastrointestinal,celiac,CVID,Primary,immunodeficiency

Contact List

Mirta Mittelstedt Leal de Sousa
contact affiliation	Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NTNU, Trondheim, Norway Proteomics and Modomics Experimental Core Facility (PROMEC) at Norwegian University of Science and Technology, Trondheim, Norway
contact email	mirta.de.sousa@ntnu.no
lab head
Animesh Sharma
contact affiliation	Engineer at NTNU, Norway
contact email	sharma.animesh@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD063461
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD063461

PRIDE project URI

Repository Record List

[ + ]