PXD063408

PXD063408 is an original dataset announced via ProteomeXchange.

Title	Serial Multi-omics Uncovers Anti-Glioblastoma Responses Not Evident by Routine Clinical Analyses (Global Proteomics)
Description	Recurrent glioblastoma (rGBM) is incurable. Serial “multi-omic” assays from longitudinal rGBM biopsies may unravel tumor responses to a treatment. Despite traditional imaging indicating tumor progression, 86 serial rGBM biopsies cores obtained over 4 months from the first two patients on a clinical trial of repeated intratumoral doses of the immunotherapeutic agent, CAN-3110, revealed therapeutic effects by multi-omic analyses, including: a-longitudinal and spatial reshaping of the rGBM’s microenvironment, b- expansion of new T cell tissue-resident effector memory clonotypes against newly characterized CAN-3110 epitopes and other undetermined antigens, and c-novel expression of HLA-immunopeptides including cancer testes antigens. The two treated patients achieved a pathologic response or stable clinical disease, respectively. These results show the value of longitudinal tissue sampling to understand GBM’s evolution during an investigational therapy.
HostingRepository	PRIDE
AnnounceDate	2025-10-08
AnnouncementXML	Submission_2025-10-08_12:07:10.969.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD063408
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Break Through Cancer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-28 13:19:55	ID requested
⏵ 1	2025-10-08 12:07:11	announced

10.1126/SCITRANSLMED.ADV2881;

10.6019/PXD063408;

submitter keyword: Glioblastoma, Proteomics

Forest M.
contact affiliation	Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
contact email	fwhite@mit.edu
lab head
Break Through Cancer
contact affiliation	Break Through Cancer
contact email	datasets@breakthroughcancer.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD063408
     1. Label: PRIDE project
     2. Name: Serial Multi-omics Uncovers Anti-Glioblastoma Responses Not Evident by Routine Clinical Analyses (Global Proteomics)