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PXD063381

PXD063381 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBioresTACs for targeted protein degradation
DescriptionBioresTAC introduces microenvironment-responsive activation: its protease-triggered design exploits dysregulated enzymes in tumors and inflamed tissues to restrict degradation activity to pathological niches. Preclinical validation in cancer and psoriasis models demonstrates enhanced efficacy with reduced off-target effects, establishing a dual-action paradigm—receptor-driven targeting and context-dependent activation—that redefines precision medicine for protein degradation therapies.
HostingRepositoryiProX
AnnounceDate2025-04-28
AnnouncementXMLSubmission_2025-04-28_00:36:46.224.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZhengcheng He
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-28 00:36:31ID requested
⏵ 12025-04-28 00:36:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: protein degradation
Contact List
Longguang Tang
contact affiliationDepartment of Orthopedic, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University
contact emailtanglongguang@zju.edu.cn
lab head
Zhengcheng He
contact affiliationDepartment of Orthopedic, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University
contact email22318607@zju.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI

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