PXD063380

PXD063380 is an original dataset announced via ProteomeXchange.

Title	Oral γδT17 cells induced by macrophages-derived extracellular vesicles in peridontitis exacerbate rheumatoid arthritis
Description	Periodontitis (PD) is one of the most common human inflammatory diseases, yet the immunological mechanism linking oral and systemic immune responses are not well defined. Here, we show that the accumulation of interleukin-17 (IL-17)-producing γδT (γδT17) cells occurs not only in the oral cavity, but also in the peripheral lymph nodes and spleens in experimental periodontitis in mice. Strikingly, oral γδT17 cells derived from experimental periodontitis migrated to the inflamed joint and led to an exacerbation of rheumatoid arthritis (RA) in a collagen-induced arthritis model in mice. Mechansitically, we demonstrated that the dysbiosis in periodontitis led to an increase in production of complement component 3 (C3)-enriched extracellular vesicles (EVs) derived from macrophages. These C3-enriched EVs were taken up by γδT cells and stimulated intracellular C3a receptor to drive IL-17A production in γδT cells. Our findings revealed an previously unrecognized immunological mechanism linking periodontitis to RA through the accumulation and migration of oral γδT17 cells.
HostingRepository	PRIDE
AnnounceDate	2026-04-08
AnnouncementXML	Submission_2026-04-07_20:08:00.132.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenzhe Wang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-27 21:40:06	ID requested
⏵ 1	2026-04-07 20:08:00	announced

Dataset with its publication pending

submitter keyword: mucosal immunity

arthritis

γδT17 cells

extracellular vesicles

C3.

Bei Li
contact affiliation	State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China.
contact email	libei2021@fmmu.edu.cn
lab head
Wenzhe Wang
contact affiliation	Hospital of Stomatology
contact email	576501855@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063380

PRIDE project URI

• PRIDE
  1. PXD063380
     1. Label: PRIDE project
     2. Name: Oral γδT17 cells induced by macrophages-derived extracellular vesicles in peridontitis exacerbate rheumatoid arthritis