PXD063376

PXD063376 is an original dataset announced via ProteomeXchange.

Title	Biomimetic Targeted Self-Adaptive Nanodrug for Inflammation Optimization and AT2 Cell Modulation in Precise ARDS Therapy
Description	Acute respiratory distress syndrome (ARDS) is a lethal respiratory condition characterized by severe alveolar damage, while effective pharmacological treatments remain elusive. Here, we identified the decreased mechanical capacity and impaired proliferation of alveolar type 2 epithelial cells (AT2) in the inflammatory environment as the primary contributors to respiratory failure of ARDS. Furthermore, a biomimetic self–adaptive HCeOx-D@PM was developed to attenuate the inflammation, improve the mechanical capacity and increase the proliferation of AT2 cells for precise ARDS therapy. HCeOx-D@PM comprises platelet membrane (PM) shell for targeted delivery to injured lungs and hollow mesoporous cerium oxide (HCeOx) core, which enables high drug loading, efficient ROS scavenging and penetrating the alveolar–capillary barrier. Initially, HCeOx-D@PM suppresses the inflammation and mitigates the adverse effects of lesions on AT2 cell by scavenging accumulated ROS. It then adaptively releases 7,8-dihydroxyflavone in response to Caspase-3 activation, facilitating AT2 cell proliferation, significantly improved survival rates in vivo, offering a promising advancement in the precise treatment of respiratory diseases.
HostingRepository	iProX
AnnounceDate	2025-04-27
AnnouncementXML	Submission_2025-04-27_20:10:55.311.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cheng Chen
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-27 20:09:51	ID requested
⏵ 1	2025-04-27 20:10:55	announced

Dataset with its publication pending

submitter keyword: Biomimetic nanodrug, inflammation alleviation, AT2 cells, ARDS therapy

Jun Deng
contact affiliation	Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University of Chinese P.L.A.)
contact email	djun.123@163.com
lab head
Cheng Chen
contact affiliation	Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education and Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University
contact email	cici0851@163.com
dataset submitter

iProX dataset URI