PXD063375
PXD063375 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Long term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats |
| Description | Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol affects the activity and expression of CYP450 enzyme is still not fully understood. In addition, existing research mainly focuses on the effects of short-term alcohol exposure, and the understanding of how long-term alcohol intake changes CYP450 enzyme function and expression is still insufficient. Therefore, this study aims to explore the effects of long-term alcohol intake on CYP450 enzyme activity through an AFLD rat model, fill the gap in existing research, reveal the specific effects and possible molecular mechanisms of long-term alcohol consumption on liver CYP450 enzyme activity and expression, and provide new insights for developing treatment strategies for AFLD. |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-27 |
| AnnouncementXML | Submission_2025-04-27_20:07:54.095.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qian Zhu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-27 20:07:40 | ID requested | |
| ⏵ 1 | 2025-04-27 20:07:54 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Alcoholic fatty liver |
Contact List
| Jun Li | |
|---|---|
| contact affiliation | Inflammation and Immune Mediated Diseases Laboratory of Anhui Province |
| contact email | lj@ahmu.edu.cn |
| lab head | |
| Qian Zhu | |
| contact affiliation | Inflammation and Immune Mediated Diseases Laboratory of Anhui Province |
| contact email | 1545559471@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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