PXD063324

PXD063324 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Tirzepatide reduces alcohol drinking, modulates reward processing, and alters lateral septum proteome in preclinical models of AUD
Description	This study explored the therapeutic potential of tirzepatide, a dual glucagon-like peptide-1 receptor (GLP-1R)/glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist, in preclinical models of AUD, while elucidating the neurobiological mechanisms mediating its effects. Our methodological approach involved reward-related behaviors, alcohol consumption paradigms, and molecular techniques including neurochemical, neurophysiological, and proteome analysis in rodents. Tirzepatide administration attenuated alcohol-induced locomotor stimulation, conditioned place preference, and accumbal dopamine release. Global proteomic analysis revealed altered histone and chromatin regulatory proteins in the lateral septum of tirzepatide-treated alcohol-consuming rats.
HostingRepository	PRIDE
AnnounceDate	2026-01-23
AnnouncementXML	Submission_2026-01-23_02:47:59.855.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes Fuchs
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-25 04:54:10	ID requested
⏵ 1	2026-01-23 02:48:00	announced

Publication List

10.1016/j.ebiom.2025.106119;
Edvardsson CE, Adermark L, Gottlieb S, Alfreji S, Emous TA, Gouda Y, Thorsell A, Vuji, č, i, ć M, Aran, ä, s C, Benrick A, Wernstedt Asterholm I, Lopez MF, Becker HC, Jerlhag E, Tirzepatide reduces alcohol drinking and relapse-like behaviours in rodents. EBioMedicine, 124():106119(2026) [pubmed]

10.1016/j.ebiom.2025.106119;

Edvardsson CE, Adermark L, Gottlieb S, Alfreji S, Emous TA, Gouda Y, Thorsell A, Vuji, č, i, ć M, Aran, ä, s C, Benrick A, Wernstedt Asterholm I, Lopez MF, Becker HC, Jerlhag E, Tirzepatide reduces alcohol drinking and relapse-like behaviours in rodents. EBioMedicine, 124():106119(2026) [pubmed]

Keyword List

submitter keyword: alcohol. ethanol, TMT, Global quantitative proteomics,Tirzepatide, preclinical models

submitter keyword: alcohol. ethanol, TMT, Global quantitative proteomics,Tirzepatide, preclinical models

Contact List

Elisabet Jerlhag
contact affiliation	Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
contact email	elisabet.jerlhag@pharm.gu.se
lab head
Johannes Fuchs
contact affiliation	Gothenburg University
contact email	johannes.fuchs@gu.se
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063324
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063324

PRIDE project URI

Repository Record List

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