⮝ Full datasets listing
PXD063268
PXD063268 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Complex human milk oligosaccharides restrict cancer cell metastasis and induce apoptosis |
| Description | Human milk oligosaccharides (HMOs) promote infant health by influencing the gut microbiome, strengthening the immune system, and potentially reducing the risk of infections. Unfortunately, complex HMOs have rarely been studied in cancers. This study examined the functional effects of the complex HMOs in blood, brain, lung, liver, breast, kidney, colon, and neuron cells to support human breastfeeding in avoiding malignancies. The influence of HMOs on cancer cell metastatic features, such as morphology, viability, mortality, adhesion, migration, and invasion, was also investigated. The eight cell lines derived from various organs were treated with HMOs at IC50 concentrations. Protein-protein interactions and pathway analysis from the proteomics approach revealed that HMOs can induce apoptosis and limit metabolic activities, resulting in cell death. Moreover, complex HMOs inhibited cancer cell adhesion, migration, invasion, and proliferation. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-04-24 |
| AnnouncementXML | Submission_2026-04-23_08:00:05.329.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dr.Wararat Chiangjong |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-24 00:05:41 | ID requested | |
| ⏵ 1 | 2026-04-23 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human milk oligosaccharides, cancer, metastasis, adhesion, invasion, proteomics |
Contact List
| Wararat Chiangjong | |
|---|---|
| lab head | |
| Dr.Wararat Chiangjong | |
| contact affiliation | Mahidol University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
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