PXD063266 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global profiling of lysine lactylation in prostate cancer cells |
| Description | Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. We identified 681 Kla sites across 379 proteins, with modifications predominantly located in nuclear and cytoplasmic proteins. Enrichment analysis indicatedrevealed Kla involvement in mRNA splicing, chromatin organization, and glycolysis/gluconeogenesis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-09_16:10:45.309.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jaeyong Kim |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-23 23:27:20 | ID requested | |
| ⏵ 1 | 2025-11-09 16:10:46 | announced | |
Publication List
| Kim JY, Sim H, Na AY, Choi SY, Lee S, Global Profiling of Lysine Lactylation in Prostate Cancer Cells. Cancer Genomics Proteomics, 22(6):929-939(2025) [pubmed] |
| 10.21873/cgp.20547; |
Keyword List
| submitter keyword: Human, Prostate, Post-translational modification |
Contact List
| Sangkyu Lee |
|---|
| contact affiliation | School of Pharmacy, Sungkyunkwan University |
| contact email | sangkyu@skku.edu |
| lab head | |
| Jaeyong Kim |
|---|
| contact affiliation | College of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea |
| contact email | rlawodyd@skku.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063266 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063266
- Label: PRIDE project
- Name: Global profiling of lysine lactylation in prostate cancer cells
