PXD063261
PXD063261 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The transcription regulator CodR promotes virulence and antibiotic resistance of Pseudomonas aeruginosa by sensing host-derived choline |
| Description | During early infection, Pseudomonas aeruginosa degrades phosphatidylcholine (PC) in host respiratory epithelial cells to release choline (Cho), facilitating colonization. However, the regulatory mechanisms underlying Cho metabolism and its role in pathogenesis remain unclear. Here, we identify CodR, a global transcriptional activator from the GcvA family, as a critical regulator of P. aeruginosa pathogenesis. CodR directly senses exogenous Cho, binding it with high affinity to activate the transcription of key virulence-associated genes, including mexA, pslA, and amrZ. Loss of CodR downregulates genes responsible for the type III secretion system (T3SS), PC degradation, extracellular polysaccharide biosynthesis, and siderophore production, leading to reduced biofilm formation and attenuated virulence in a murine pneumonia model. Remarkably, CodR-mediated Cho sensing also upregulates antibiotic resistance genes, enhancing bacterial survival under diverse antibiotic treatments. These findings reveal how CodR integrates host-derived signals to modulate bacterial virulence and antibiotic resistance, offering new insights into host-pathogen interactions and potential therapeutic strategies |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-24 |
| AnnouncementXML | Submission_2025-04-23_20:16:04.595.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Derong Dai |
| SpeciesList | scientific name: Pseudomonas aeruginosa UCBPP-PA14; NCBI TaxID: 208963; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Thermo Fisher Scientific instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-23 20:15:53 | ID requested | |
| ⏵ 1 | 2025-04-23 20:16:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Pseudomonas aeruginosa,transcription regulator,virulence,antibiotic resistance |
Contact List
| Yingjie Song | |
|---|---|
| contact affiliation | College of Life Science, Sichuan Normal University |
| contact email | 1127551970@qq.com |
| lab head | |
| Derong Dai | |
| contact affiliation | Sichuan University |
| contact email | 2107429907@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
