PXD063243 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Naloxone induced alterations in liver proteome and cholesterol level in ApoE-/- mice. |
| Description | The endogenous opioid system plays a pivotal role in numerous physiological processes and is implicated in a range of diseases, including atherosclerosis, a condition contributing to nearly 50% of deaths in Western societies. This study investigates the effects of opioid receptor blockade using naloxone, on the plasma lipid profile and atherosclerosis progression. ApoE-/- mice with advanced atherosclerosis were treated with naloxone for seven days, and the effects on atherosclerotic plaque development and liver steatosis were evaluated. Proteomic analysis of liver samples post-treatment, identified 384 proteins with altered expression. The results revealed that naloxone treatment led to increase in HDL cholesterol, a lipid fraction associated with protective cardiovascular effects. Furthermore, naloxone did not influence the progression of atherosclerotic plaques or the development of liver steatosis. In conclusion, while short-term naloxone treatment in mice with advanced atherosclerosis does not alter overall atherosclerotic plaque progression or liver steatosis, the observed elevation in HDL cholesterol and the extensive changes in liver protein expression underscore the complex and multifaceted role of the opioid system in lipid metabolism and cardiovascular health. These findings provide a foundation for further exploration of opioid receptor antagonists as modulators of lipid profiles and potential contributors to cardiovascular therapy. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_17:56:27.982.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Maciej Suski |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-23 06:17:17 | ID requested | |
| ⏵ 1 | 2026-02-08 17:56:29 | announced | |
Publication List
| Jasku, ł, a K, Nawrocka A, Pozna, ń, ski P, Stachowicz A, Ł, azarczyk M, Sacharczuk M, Gaciong Z, Skiba DS, Targeting the Opioid System in Cardiovascular Disease: Liver Proteomic and Lipid Profile Effects of Naloxone in Atherosclerosis. Biomedicines, 13(8):(2025) [pubmed] |
| 10.3390/biomedicines13081802; |
Keyword List
| submitter keyword: opioid receptors |
| cholesterol |
| atherosclerotic plaque |
| liver steatosis |
Contact List
| Dominik Skiba |
|---|
| contact affiliation | Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Poland |
| contact email | skiba.dominik@gmail.com |
| lab head | |
| Maciej Suski |
|---|
| contact affiliation | Chair of Pharmacology |
| contact email | maciej.suski@uj.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063243
- Label: PRIDE project
- Name: Naloxone induced alterations in liver proteome and cholesterol level in ApoE-/- mice.
