PXD063198

PXD063198 is an original dataset announced via ProteomeXchange.

Title	Brain-derived extracellular vesicle proteomics reveals neuroprotection induced by the ARB candesartan in Parkinson’s disease patients
Description	In models of Parkinson’s disease (PD), angiotensin-II type-1 receptor (AT1) blockers (ARBs) mitigated the vulnerability ofdopaminergic neurons, which aligns with recent transcriptomic studies of human brains showing increased susceptibility ofdopaminergic neurons with high AGTR1 expression, and with epidemiological data indicating an ARB-related reduction in PDincidence. However, there is no experimental evidence in PD patients. Using a minimally invasive strategy based on the isolation ofblood extracellular vesicles (EVs) from neuronal, microglial/macrophage, astrocytic, and oligodendrocytic origin, we report proteomicprofiles from patients treated with the ARB candesartan. Candesartan treatment led to the differential expression of key proteinsinvolved in PD pathogenesis: 46 in neuron-derived EVs, 48 in microglia/macrophage-derived EVs, 22 in astrocyte-derived EVs, and 92in oligodendrocyte-derived EVs. Our findings provide the first direct molecular evidence of neuroprotective mechanisms triggered byARBs in PD patients and support the rationale for larger clinical trials on ARB repurposing.
HostingRepository	PRIDE
AnnounceDate	2025-12-06
AnnouncementXML	Submission_2025-12-06_04:19:56.576.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susana Bravo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-22 08:34:08	ID requested
⏵ 1	2025-12-06 04:19:57	announced

10.1038/S41531-025-01230-6;

submitter keyword: None

Ana Isabel Rodriguez-Perez
contact affiliation	Research Center for Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago deCompostela, Spain
contact email	anai.rodriguez@usc.es
lab head
Susana Bravo
contact affiliation	FIDIS
contact email	sbbravo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063198

PRIDE project URI

• PRIDE
  1. PXD063198
     1. Label: PRIDE project
     2. Name: Brain-derived extracellular vesicle proteomics reveals neuroprotection induced by the ARB candesartan in Parkinson’s disease patients