PXD063187

PXD063187 is an original dataset announced via ProteomeXchange.

Title	A Tale of Two Follicles: Proteomic Clues to Oocyte Success and Failure
Description	Women are born with thousands of follicles in their ovaries but less than 1% will produce a mature oocyte. What distinguishes the 99% of ovarian follicles destined for demise from the rare 1% that succeed? Here, we leveraged a unique clinical opportunity, paired follicular fluid samples from small antral follicles containing viable and atretic oocytes, to uncover the proteomic determinants governing oocyte fate. Our analysis identified nearly 1,500 proteins, revealing that healthy follicular fluid is enriched with proteins crucial for energy metabolism, antioxidative defense, structural integrity, and robust signaling networks, supporting successful oocyte survival and maturation. In contrast, atretic follicles exhibited a distinct inflammatory signature characterized by acute-phase and immune activation proteins, indicative of active degeneration. These novel proteomic insights deepen our understanding of follicle biology and open new avenues for biomarker development, optimization of assisted reproductive technologies, and targeted therapeutic strategies to preserve and enhance female fertility.
HostingRepository	PRIDE
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-29_16:55:04.227.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jeovanis Gil
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-22 05:33:43	ID requested
⏵ 1	2026-03-29 16:55:05	announced

10.1038/s41598-026-40907-7;

Kristensen SG, Subiran Adrados C, Elsner K, Cadenas J, Jensen LB, Tanvig MH, Greve VH, Colmorn LB, Marko-Varga G, Malm J, Gil J, Molecular signatures of oocyte viability identified by follicular fluid proteomics. Sci Rep, 16(1):(2026) [pubmed]

submitter keyword: Metabolism, Atresia, Fertility preservation, Oocyte maturation,Follicular Fluid

Jeovanis Gil
contact affiliation	Department of Translational Medicine, Lund University
contact email	jeovanis.gil_valdes@med.lu.se
lab head
Jeovanis Gil
contact affiliation	Lund University
contact email	jeovanis.gil_valdes@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD063187

PRIDE project URI

• PRIDE
  1. PXD063187
     1. Label: PRIDE project
     2. Name: A Tale of Two Follicles: Proteomic Clues to Oocyte Success and Failure