⮝ Full datasets listing
PXD063175
PXD063175 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TimsTOF-Based DIA Proteomic Profiling of Cisplatin-Resistant and Sensitive MDA-MB-231 Triple-Negative Breast Cancer Cell Lines |
| Description | This dataset presents data-independent acquisition (DIA)-based proteomic profiles generated using a timsTOF Pro mass spectrometer for cisplatin-resistant (cisR) and cisplatin-sensitive (cisS) MDA-MB-231 triple-negative breast cancer (TNBC) cell lines. The objective was to decipher proteomic alterations associated with cisplatin resistance. The analysis uncovered significant upregulation of extracellular matrix (ECM) remodeling proteins (e.g., COL6A1, COL6A2, COL6A3), and invasion-related membrane proteins (e.g., TIMP1, MMP-14, APP) in cisR cells. The dataset offers high-resolution, reproducible proteomic insights into the mechanisms of cisplatin resistance, emphasizing the role of EMT, metabolic reprogramming, and membrane remodeling in TNBC. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-04-22 |
| AnnouncementXML | Submission_2026-04-21_08:00:04.385.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shashwati |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-21 22:43:06 | ID requested | |
| ⏵ 1 | 2026-04-21 08:00:04 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cisplatin resistance, TNBC, MDA-MB-231, DIA proteomics, timsTOF, mass spectrometry, ECM remodeling, lipid metabolism, EMT |
Contact List
| Prof. Sanjeeva Srivastava | |
|---|---|
| lab head | |
| Shashwati | |
| contact affiliation | IIT Bombay |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003773/ |
