PXD063171 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Osteogenic differentiation regulation of canine periodontal ligament stem cells by hydrogel containing magnetic nanoparticles |
| Description | Bone defect architecture has become an issue to resemble in scaffold properties, beside enhancing osteoinduction. Thus, a non-invasive injectable approach is proposed by using silk fibroin (SF)-based hydrogel containing magnetic nanohydroxyapatite (MHAp) and osteogenic growth peptide (OGP). This study aimed to disseminate the osteogenic differentiation potential of the hydrogel and its mechanism on canine periodontal ligament stem cells (cPDLSCs). The addition of MHAp and/or OGP into the hydrogel shows remarkable osteogenic differentiation by the elevated ALP activity, osteogenic marker expression, and biomineralization. Proteomics analysis results revealed that TGF-β, BMP, and Notch signaling pathways are involved in the injectable hydrogel-induced osteogenic differentiation of cPDLSCs, validated by inhibition assay. Overall, HG/OGP/MHAp shows potential to be used in clinical practice for treating alveolar bone defects. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:49:47.958.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Poorichaya Somparn |
| SpeciesList | scientific name: Canis lupus lupus; NCBI TaxID: NEWT:443256; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-21 21:19:19 | ID requested | |
| ⏵ 1 | 2026-05-24 16:49:48 | announced | |
Publication List
| Purbantoro SD, Scatena M, Taephatthanasagon T, Rodprasert W, Somparn P, Nanthawong S, Makjaroen J, Jantaratana P, Mahanonda R, Sa-Ard-Iam N, Osathanon T, Tabtieang SP, Sawangmake C, Rattanapuchpong S, Magnetic nanohydroxyapatite-peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis. Vet Q, 46(1):2672558(2026) [pubmed] |
| 10.1080/01652176.2026.2672558; |
Keyword List
| submitter keyword: hydrogel,Osteogenic, canine periodontal ligament stem cells |
Contact List
| Poorichaya Somparn |
|---|
| contact affiliation | Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand |
| contact email | poorichaya.s@chula.ac.th |
| lab head | |
| Poorichaya Somparn |
|---|
| contact affiliation | Chulalongkorn university |
| contact email | poorichaya.s@chula.ac.th |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD063171 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063171
- Label: PRIDE project
- Name: Osteogenic differentiation regulation of canine periodontal ligament stem cells by hydrogel containing magnetic nanoparticles
