PXD063136

PXD063136 is an original dataset announced via ProteomeXchange.

Title	Scutellariae Radix and Atractylodis Macrocephalae Rhizoma pairs ameliorate preeclampsia via PI3K/AKT/eNOS pathway
Description	To investigate the underlying mechanisms of Scutellariae Radix and Atractylodis Macrocephalae Rhizoma (SA) in treating preeclampsia (PE), particularly its pathogenic regulation and pharmacodynamic actions, we performed a comprehensive proteomic analysis using placental tissues from three experimental groups of pregnant rats: control, PE model, and medium-dose SA treatment. The extracted proteomes were analyzed using stable isotope dimethyl labeling coupled with HPLC-MS/MS technology. This integrated approach enabled systematic identification and quantification of differentially expressed proteins associated with PE pathogenesis and SA-mediated therapeutic effects, providing molecular-level insights into the biological responses to SA intervention.
HostingRepository	iProX
AnnounceDate	2025-04-18
AnnouncementXML	Submission_2025-04-20_22:17:36.225.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-20 22:17:22	ID requested
⏵ 1	2025-04-20 22:17:36	announced

Dataset with its publication pending

submitter keyword: Preeclampsia, Scutellariae Radix, Atractylodis Macrocephalae Rhizoma, PI3K/AKT/eNOS pathway

Yong Liu
contact affiliation	College of Life Science, Fuyang Normal College
contact email	200906008@fynu.edu.cn
lab head
Yue Yang
contact affiliation	School of Pharmacy, Lanzhou University
contact email	18192871946@163.com
dataset submitter

iProX dataset URI