PXD063133 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of Prote-a-Tac |
| Description | The 26S proteasome recognizes substrates via ubiquitin receptors, a mechanism we leveraged to develop a small molecule ligand- and ubiquitination-independent targeted protein degradation strategy. Our proteasome-targeting chimera, Prote-a-Tac, links a proteasomal Ub receptor (PSMD4 or ADRM1) with a target-specific antibody fragment (such as a scFv or nanobody), allowing it to integrate into the proteasome and promote ubiquitin-independent degradation. The Prote-a-Tac platform demonstrated high specificity and minimal off-target effects, as confirmed by quantitative mass spectrometry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-06 |
| AnnouncementXML | Submission_2026-07-05_23:37:19.121.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dohyun Han |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-20 20:56:10 | ID requested | |
| ⏵ 1 | 2026-07-05 23:37:19 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TMT, degradation,Proteasome |
Contact List
| Dohyun Han |
|---|
| contact affiliation | Proteomics core facility, Biomedical Research Institute, Seoul National Unviersity Hospital |
| contact email | hdh03@snu.ac.kr |
| lab head | |
| Dohyun Han |
|---|
| contact affiliation | Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
| contact email | hdh03@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD063133 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063133
- Label: PRIDE project
- Name: Proteomic analysis of Prote-a-Tac
