PXD063126

PXD063126 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DIA-Based Phosphoproteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury
Description	Acetaminophen (APAP) overdose can lead to acute kidney injury (AKI), yet its molecular mechanisms remain unclear and no effective treatments are currently available. In this study, we combined transcriptomic, proteomic, and phosphoproteomic profiling of kidneys from APAP-exposed mice to explore molecular mechanisms and potential therapeutic strategies. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP treatment. Acute kidney injury was induced by intraperitoneal injection of APAP overdose (300 mg/kg body weight) for 6 hours (n = 4). Control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were subsequently collected from APAP-induced kidney injury mice and PBS-injected controls.
HostingRepository	PRIDE
AnnounceDate	2025-12-05
AnnouncementXML	Submission_2025-12-05_01:10:07.485.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianxin Zheng
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-19 09:23:42	ID requested
⏵ 1	2025-12-05 01:10:08	announced

Publication List

10.1080/0886022x.2025.2580064;
Zheng J, Lai P, Wu J, Li Y, Chen F, Zhu D, A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. Ren Fail, 47(1):2580064(2025) [pubmed]

10.1080/0886022x.2025.2580064;

Zheng J, Lai P, Wu J, Li Y, Chen F, Zhu D, A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. Ren Fail, 47(1):2580064(2025) [pubmed]

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Jianxin Zheng
contact affiliation	Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China
contact email	zheng.jianxin@zsxmhospital.com
lab head
Jianxin Zheng
contact affiliation	Department of Urology, Zhongshan Hospital (Xiamen), Fudan University
contact email	zheng.jianxin@zsxmhospital.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063126
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063126

PRIDE project URI

Repository Record List

[ + ]