PXD063122

PXD063122 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DIA-Based Proteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury
Description	Acetaminophen (APAP) overdose can cause acute kidney injury (AKI), but its molecular mechanisms remain poorly understood and no effective treatments are currently available. In this study, we performed an integrated analysis combining transcriptomic, proteomic, and phosphoproteomic profiling of kidney tissues from APAP-treated mice to investigate the underlying molecular mechanisms and identify potential therapeutic targets. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP administration. AKI was induced by intraperitoneal injection of a high dose of APAP (300 mg/kg body weight) for 6 hours (n = 4), while control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were collected from both APAP-treated and control groups for downstream omics analyses.
HostingRepository	PRIDE
AnnounceDate	2025-11-24
AnnouncementXML	Submission_2025-11-23_16:09:13.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianxin Zheng
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-19 01:54:05	ID requested
⏵ 1	2025-11-23 16:09:14	announced

Publication List

10.1080/0886022x.2025.2580064;
Zheng J, Lai P, Wu J, Li Y, Chen F, Zhu D, A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. Ren Fail, 47(1):2580064(2025) [pubmed]

10.1080/0886022x.2025.2580064;

Zheng J, Lai P, Wu J, Li Y, Chen F, Zhu D, A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. Ren Fail, 47(1):2580064(2025) [pubmed]

Keyword List

submitter keyword: mouse, kidney, acetaminophen, proteome, acute kidney injury

submitter keyword: mouse, kidney, acetaminophen, proteome, acute kidney injury

Contact List

Jianxin Zheng
contact affiliation	Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China
contact email	zheng.jianxin@zsxmhospital.com
lab head
Jianxin Zheng
contact affiliation	Department of Urology, Zhongshan Hospital (Xiamen), Fudan University
contact email	zheng.jianxin@zsxmhospital.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063122
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063122

PRIDE project URI

Repository Record List

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