PXD063107

PXD063107 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PISA Assay of B1 antibiotic on Neisseria gonorrhoeae
Description	Study on antibiotic B1 and for target identification and mode of action characterization on Neisseria gonorrhoeae Strain, using Proteome Integral Solubility Alteration (PISA) Assay
HostingRepository	PRIDE
AnnounceDate	2026-01-19
AnnouncementXML	Submission_2026-01-18_16:57:29.317.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Massimiliano Gaetani
SpeciesList	scientific name: Neisseria gonorrhoeae; NCBI TaxID: NEWT:485;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-18 06:56:56	ID requested
⏵ 1	2026-01-18 16:57:30	announced

Publication List

10.1016/j.cell.2025.07.033;
Krishnan A, Anahtar MN, Valeri JA, Jin W, Donghia NM, Sieben L, Luttens A, Zhang Y, Modaresi SM, Hennes A, Fromer J, Bandyopadhyay P, Chen JC, Rehman D, Desai R, Edwards P, Lach RS, Aschtgen MS, Gaborieau M, Gaetani M, Palace SG, Omori S, Khonde L, Moroz YS, Blough B, Jin C, Loh E, Grad YH, Saei AA, Coley CW, Wong F, Collins JJ, A generative deep learning approach to de novo antibiotic design. Cell, 188(21):5962-5979.e22(2025) [pubmed]

10.1016/j.cell.2025.07.033;

Krishnan A, Anahtar MN, Valeri JA, Jin W, Donghia NM, Sieben L, Luttens A, Zhang Y, Modaresi SM, Hennes A, Fromer J, Bandyopadhyay P, Chen JC, Rehman D, Desai R, Edwards P, Lach RS, Aschtgen MS, Gaborieau M, Gaetani M, Palace SG, Omori S, Khonde L, Moroz YS, Blough B, Jin C, Loh E, Grad YH, Saei AA, Coley CW, Wong F, Collins JJ, A generative deep learning approach to de novo antibiotic design. Cell, 188(21):5962-5979.e22(2025) [pubmed]

Keyword List

submitter keyword: proteomics, LC-MS, mode of action, antibiotic,target ID, bacteria, PISA assay

submitter keyword: proteomics, LC-MS, mode of action, antibiotic,target ID, bacteria, PISA assay

Contact List

Massimiliano Gaetani
contact affiliation	Chemical Proteomics, Division of Chemistry I, MBB Dept., Biomedicum, Karolinska Insitute, Stockholm, Sweden
contact email	massimiliano.gaetani@ki.se
lab head
Massimiliano Gaetani
contact affiliation	Karolinska Institutet
contact email	massimiliano.gaetani@ki.se
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063107
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063107

PRIDE project URI

Repository Record List

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