PXD063056

PXD063056 is an original dataset announced via ProteomeXchange.

Title	Transgelin modulates HBV replication and transcription via OPA1-mediated mitochondrial dynamics
Description	Hepatitis B virus (HBV) hijacks host proteins to manipulate cellular physiology and metabolism, facilitating its replication. Transgelin 2 (TAGLN2) ，an actin-binding protein, is highly expressed in HBV-associated hepatocellular carcinoma, yet its role in viral infection remains unclear. I Here, we demonstrated that HBV upregulated TAGLN expression in vitro and in vivo. TAGLN depletion impaired HBV replication and transcription while promoted mitochondrial fission and enhanced ATP production. Through mitochondrial proteomics, we identified Optic Atrophy 1 (OPA1)，a key dynamin governing mitochondrial fusion, as a downstream effector. Silencing OPA1 downregulated TAGLN and suppressed HBV replication, whereas OPA1 overexpression exerted the opposite effects. Mechanistically, TAGLN and OPA1 form a reciprocal regulatory axis to sustain HBV propagation. Our study unveils a novel TAGLN-OPA1 axis critical for HBV replication, providing insights into host-directed antiviral strategies.
HostingRepository	iProX
AnnounceDate	2025-04-15
AnnouncementXML	Submission_2025-04-17_01:20:23.035.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Wen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-17 01:20:06	ID requested
⏵ 1	2025-04-17 01:20:23	announced

Dataset with its publication pending

submitter keyword: TAGLN, HBV, Mitochondria, OPA1

Huan Wang
contact affiliation	Zunyi Medical University
contact email	wanghuan928@163.com
lab head
Juan Wen
contact affiliation	Zunyi Medical University
contact email	476327767@qq.com
dataset submitter

iProX dataset URI