PXD063013

PXD063013 is an original dataset announced via ProteomeXchange.

Title	Study on the spatial effect of peripheral ApoE3 on regulating cadmium binding proteome and mechanism of cognitive impairment in the elderly
Description	The experiment utilized a total of 54 five-week-old Sprague-Dawley rats, each weighing approximately 100 grams. These rats were randomly divided into 9 groups, consisting of 27 female and 27 male rats. Based on the intervention dose of cadmium (Cd), the rats were further randomly assigned into 3 main groups, each containing 18 rats: the control group received 1 milliliter of sodium chloride solution daily; the low-dose group received 1 milliliter of cadmium chloride (CdCl₂) solution at a concentration of 30 micrograms per kilogram (μg/kg) daily; and the high-dose group received 1 milliliter of cadmium chloride (CdCl₂) solution at a concentration of 1 milligram per kilogram (mg/kg) daily. Cadmium exposure was administered via oral gavage. Each dose group (control group, low-dose group, and high-dose group) was intervened at three different time points: 2 weeks, 4 weeks, and 8 weeks. At each intervention time point, 6 rats were randomly selected from each dose group for euthanasia, and their prefrontal brain tissues were collected for subsequent analysis. During the experiment, some rats died: 2 rats in the control group died at 2 weeks, and 1 rat in the high-dose group died at 4 weeks and 8 weeks, respectively. The experimental design ensured a systematic evaluation of the effects of cadmium exposure on rats under different doses and time points, while recording the mortality during the experiment for further analysis.
HostingRepository	iProX
AnnounceDate	2025-04-16
AnnouncementXML	Submission_2025-05-19_00:18:41.151.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sheng Wan
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-16 01:26:44	ID requested
1	2025-04-16 01:27:05	announced
⏵ 2	2025-05-19 00:18:41	announced	2025-05-19: Add Publication.

Wan S, Yang Y, Zhao Q, Xing Z, Li J, Gao H, Yin Y, Liu Z, Chen Q, Tian M, Shi X, Ji Z, Huang S, Proteomic signatures and predictive modeling of cadmium-associated anxiety in middle-aged and elderly populations: an environmental exposure association study. J Transl Med, 23(1):499(2025) [pubmed]

submitter keyword: Cadmium, proteomics, cognitive impairment, aging, Environment-Gene-Protein

Shaoxin Huang
contact affiliation	Jiujiang University
contact email	huangshaoxinok@163.com
lab head
Sheng Wan
contact affiliation	Jiujiang University
contact email	17381280325@163.com
dataset submitter

iProX dataset URI