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PXD062978

PXD062978 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1
DescriptionDerailed gene expression programs within the developing nervous system, encompassing both transcriptional and posttranscriptional processes, can cause diverse neurodevelopmental diseases (NDD). The NDD FOXG1-syndrome lacks full understanding of the mechanistic role of its eponymous gene product. While it is known that FOXG1 acts in part at the chromatin by binding to regulative regions, it is unclear what factors control its presence at specific sites. Long non-coding RNAs (lncRNAs) can mediate site-directed transcription factor binding, but their potential role in FOXG1-syndrome has not been described. Here, we show that FOXG1 localisation is regulated at selected loci through the lncRNA Pantr1. We identified FOXG1 as an upstream transcriptional activator of Pantr1 in human and mice. Further, we discovered that FOXG1 has the ability to associate with RNAs. Both, transcriptional regulation of Pantr1 by FOXG1 and association of both partners, build up a regulative network that impacts the localisation of FOXG1 at selected genomic loci. Specifically, Pantr1 facilitates cooperative presence of FOXG1/NEUROD1 at specific sites, and Pantr1 reduction leads to redistribution of FOXG1 to comparably more generic binding sites. The rescue of impaired dendritic outgrowth upon FOXG1 reduction by simultaneous overexpression of Pantr1 underlines the importance of the FOXG1/Pantr1 regulative network.
HostingRepositoryMassIVE
AnnounceDate2025-05-21
AnnouncementXMLSubmission_2025-05-21_03:44:31.120.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterStefan Tholen
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF fleX
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-15 05:16:35ID requested
12025-05-21 03:44:31announced
Publication List
no publication
Keyword List
submitter keyword: hippocampus, Rett, transcription, neuron, neurite outgrowth, FOXG1, DatasetType:Proteomics
Contact List
Prof. Dr. Tanja Vogel
contact affiliationInstitute for Anatomy and Cell Biology
contact emailtanja.vogel@anat.uni-freiburg.de
lab head
Stefan Tholen
contact affiliationUniklinik Freiburg
contact emailstefan.tholen@uniklinik-freiburg.de
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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