PXD062955

PXD062955 is an original dataset announced via ProteomeXchange.

Title	SWATH-MS-based proteome analysis of PBA-enriched glycated/ glycosylated proteins from knee synovial fluid in osteoarthritis (OA) and osteoarthritis with type 2 diabetes mellitus (OADM)
Description	Osteoarthritis (OA) severity is often exacerbated in individuals with type 2 diabetes mellitus (T2DM), giving rise to a co-morbid condition (OADM) characterized by enhanced metabolic and degenerative alterations. However, the molecular mechanisms underlying this association remain insufficiently understood. In this study, we performed a SWATH-MS-based global proteomic analysis of phenylboronic acid (PBA)-enriched cis-diol–containing glycated/ glycosylated proteins from knee synovial fluid samples of OA and OADM patients. The dataset captures differentially abundant protein signatures associated with metabolic dysregulation, extracellular matrix remodeling, and inflammatory processes in OADM. From a translational perspective, these proteins may have potential relevance as candidate biomarkers for distinguishing OADM from OA and for supporting future investigations into disease stratification and targeted therapeutic approaches.
HostingRepository	PRIDE
AnnounceDate	2026-03-27
AnnouncementXML	Submission_2026-03-26_23:17:26.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ayushi Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-14 18:20:16	ID requested
⏵ 1	2026-03-26 23:17:26	announced

10.1186/S12967-026-07984-8;

submitter keyword: None

Jyotdeep Kaur
contact affiliation	Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh - 160012, India
contact email	jyotdeep2001@yahoo.co.in
lab head
Ayushi Sharma
contact affiliation	Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh - 160012, India
contact email	ayushisharma3194@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD062955

PRIDE project URI

• PRIDE
  1. PXD062955
     1. Label: PRIDE project
     2. Name: SWATH-MS-based proteome analysis of PBA-enriched glycated/ glycosylated proteins from knee synovial fluid in osteoarthritis (OA) and osteoarthritis with type 2 diabetes mellitus (OADM)