PXD062940

PXD062940 is an original dataset announced via ProteomeXchange.

Title	Chronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment
Description	About 1 in 10 U.S. newborns are born preterm and often require sedation, which may pose long-term neurodevelopmental risks. This study examined the effects of chronic exposure to midazolam (MDZ), a sedative commonly used in NICUs, using a rodent model. Researchers assessed physical, molecular, biochemical, and behavioral outcomes across development. Results showed that early MDZ exposure led to early childhood growth issues, abnormal weight gain patterns in adulthood (suggesting a risk of binge eating), reduced dopamine release, increased brain inflammation markers, and signs of anxiety and social deficits in adolescence. The study highlights potential long-term impacts of neonatal MDZ use on brain and behavior.
HostingRepository	PRIDE
AnnounceDate	2025-10-27
AnnouncementXML	Submission_2025-10-26_18:06:51.684.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gurudutt Pendyala
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-14 09:40:59	ID requested
⏵ 1	2025-10-26 18:06:52	announced

Nguyen NM, Athota P, Flores A, Trease A, Meyer D, Singu VK, Krishnamoorthy C, Schaal VL, Bhakat R, Sualy K, Natarajan SK, Stauch K, Yelamanchili SV, Pendyala G, Comprehensive characterization of chronic midazolam exposure on neonates and long-term neurodevelopment. Mol Psychiatry, 30(11):5203-5214(2025) [pubmed]

10.1038/s41380-025-03104-y;

submitter keyword: Midazolam,Neurodevelopment

Dr. Gurudutt N. Pendyala
contact affiliation	Head of Pendyala Lab Robert Lieberman Endowed Professor of Anesthesiology University of Nebraska Medical Center College of Medicine,Department of Anesthesiology Omaha,Nebraska,United states.
contact email	gpendyala@unmc.edu
lab head
Gurudutt Pendyala
contact affiliation	University of Nebraska Medical Center
contact email	gpendyala@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD062940

PRIDE project URI

• PRIDE
  1. PXD062940
     1. Label: PRIDE project
     2. Name: Chronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment