PXD062924

PXD062924 is an original dataset announced via ProteomeXchange.

Title	Metabolomic and Proteomic Analysis of Renal Function After Liver Transplantation
Description	Background: Renal dysfunction is a common and serious complication in patients with end-stage liver diseases. While some patients recover renal function after liver transplantation (LT), others do not. Additionally, patients with normal kidney function (Normal-KF) before LT may develop post-transplant renal dysfunction. Early identification of patients at risk for impaired kidney function (Impaired-KF) post-LT is critical to improving outcomes. This study integrated metabolomic and proteomic analyses to investigate molecular profiles distinguishing Normal-KF from Impaired-KF post-LT. Methods: Nine LT recipients were classified into Normal-KF (n=5) and Impaired-KF (n=4) groups. One additional recipient with pre-transplant renal function impairment who recovered renal function after LT, was analyzed separately. Plasma samples were collected at 2- and 5-weeks post-LT. The metabolomic and proteomic profiles were assessed by untargeted liquid chromatography-tandem mass spectrometry. Results: Metabolomic analysis identified 29 significantly altered metabolites between Normal-KF and Impaired-KF (fold change>2, p<0.05). Proteomic analysis revealed 45 differentially expressed proteins (fold change>1.25, p<0.05). For the recovered patient, the metabolomic profile closely resembled Normal-KF, whereas the proteomic profile remained aligned with Impaired-KF at both 14- and 35-days post-LT. From week 2 to week 5, both the metabolomic and proteomic profiles of the recovered patient showed trends toward the Normal-KF. Conclusion: This study revealed distinct metabolomic and proteomic signatures associated with renal dysfunction post-LT. Proteomic profiles indicated a delayed recovery compared to metabolomic profiles, suggesting a dynamic and muti-layered renal recovery process. Further research is warranted to elucidate the functional implications of the differential proteins and metabolites for improved monitoring and therapeutic strategies.
HostingRepository	PRIDE
AnnounceDate	2025-05-26
AnnouncementXML	Submission_2025-05-25_16:09:35.896.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaoling Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-14 04:27:15	ID requested
⏵ 1	2025-05-25 16:09:36	announced

10.3389/frtra.2025.1572852;

Wang X, Grobe N, Franchin B, Levitsky J, Cravedi P, Kotanko P, Metabolomic and proteomic analyses of renal function after liver transplantation. Front Transplant, 4():1572852(2025) [pubmed]

submitter keyword: proteomics, metabolomics, Renal dysfunction,Liver transplantation

Xiaoling Wang
contact affiliation	Fresenius Medical Care
contact email	xiaoling.wang@rriny.com
lab head
Xiaoling Wang
contact affiliation	Renal Research Institute
contact email	xiaolingw@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD062924
     1. Label: PRIDE project
     2. Name: Metabolomic and Proteomic Analysis of Renal Function After Liver Transplantation