PXD062913
PXD062913 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Analysis of Nucleocytoplasmic Protein Separation in DPST-Crosslinked Human Neuroblastoma SY5Y Cells |
Description | Following DPST crosslinking of human neuroblastoma cells, nuclear-cytoplasmic fractionation was performed using hypotonic lysis to obtain cytoplasmic and nuclear protein compartments. Through systematic analysis of crosslinking mass spectrometry data, we elucidated how subcellular compartmentalized microenvironments regulate spatial distribution of protein conformations and topological architecture of interaction networks. This study reveals the heterogeneous principles governing dynamic protein assembly between nuclear and cytoplasmic compartments in neuroblastoma cells. |
HostingRepository | iProX |
AnnounceDate | 2025-04-14 |
AnnouncementXML | Submission_2025-04-14_00:37:00.861.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jing Chen |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-04-14 00:34:39 | ID requested | |
⏵ 1 | 2025-04-14 00:37:01 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: crosslinking, nuclear, cytoplasmic |
Contact List
Lihua Zhang | |
---|---|
contact affiliation | Dalian Institute of Chemical Physics, Chinese Academy of Sciences |
contact email | lihuazhang@dicp.ac.cn |
lab head | |
Jing Chen | |
contact affiliation | Dalian Institute of Chemical Physics, Chinese Academy of Sciences |
contact email | chenj1810@dicp.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |