PXD062908

PXD062908 is an original dataset announced via ProteomeXchange.

Title	N-terminal formylation-dependent protein interactions in human cells
Description	N-terminal formylation of methionine is a unique protein modification found in prokaryotes, as well as in the mitochondria, chloroplasts, and even the cytosol of eukaryotic cells. Recent studies have revealed that human cells are capable of producing cytosolic proteins bearing N-terminal formylmethionine. This project aims to investigate N-terminal formylation-dependent interaction changes of the human tumor protein TPD54. Specifically, HeLa cells were transfected with TPD54-BirA*, along with either E. coli formyltransferase (EcFMT) or its catalytically inactive R43L mutant, to manipulate the formylation status.
HostingRepository	jPOST
AnnounceDate	2026-06-04
AnnouncementXML	Submission_2026-06-03_08:00:05.248.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dasom Kim
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; N-formyl-L-proline; N6-biotinyl-L-lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-13 22:26:17	ID requested
⏵ 1	2026-06-03 08:00:05	announced

Dataset with its publication pending

submitter keyword: BioID, PPI

Cheol-Sang Hwang
lab head
Dasom Kim
contact affiliation	Korea university
dataset submitter

jPOST dataset URI

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