PXD062891

PXD062891 is an original dataset announced via ProteomeXchange.

Title	Adaptive Regulatory Mechanisms of the Proteome and Phosphorylation Modifications in Multiple Organs of Mice during Torpor
Description	Torpor is a crucial adaptive strategy employed by mammals to cope with low-temperature environments and/or seasonal food shortages. Investigating the torpor behavior of animals not only helps to elucidate their ecological adaptation mechanisms under conditions of food scarcity and harsh environments but also provides potential scientific insights for exploring organ transplantation, delaying aging, and extending lifespan. In this study, we established a torpor model using C57BL mice subjected to fasting and water deprivation at environmental temperatures of 22℃, 17℃, and 12℃. Through a combination of ultrastructural histology, proteomics, molecular biology, network analysis, and bioinformatics, we systematically analyzed the changes in protein expression and phosphorylation modification regulation in the kidney, liver, heart, and brown adipose tissue (BAT) of torpid mice. Notably, proteins such as phosphoenolpyruvate carboxykinase (PCK), tyrosine aminotransferase (TAT), and microtubule-associated protein 2 (MAP2) play significant roles during the torpor state in mice. These findings lay a crucial foundation for a deeper understanding of the molecular regulatory mechanisms underlying mammalian torpor and their tolerance strategies in adverse environments.
HostingRepository	iProX
AnnounceDate	2025-04-11
AnnouncementXML	Submission_2025-04-13_19:57:58.711.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ningmei Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-13 19:57:05	ID requested
⏵ 1	2025-04-13 19:57:59	announced

Dataset with its publication pending

submitter keyword: Torpor, Regulation, Proteomics, Physiological Adaptation

Hui Wang
contact affiliation	Hebei Normal University
contact email	whui1981@163.com
lab head
Ningmei Wang
contact affiliation	Hebei Normal University
contact email	767247571@qq.com
dataset submitter

iProX dataset URI