PXD062888

PXD062888 is an original dataset announced via ProteomeXchange.

Title	Orbitrap proteomic analysis of five distinct molecular subtypes of High Grade Serous Ovarian Carcinoma (HGSOC) under serum deprived and serum fed conditions
Description	Cell lines representing five distinct phenotypes of high-grade serous ovarian carcinoma (HGSOC), including Epithelial (E), Intermediate-Epithelial (iE), Epithelial-Mesenchymal Hybrid (E/M), Intermediate-Mesenchymal (iM), and Mesenchymal (M), previously classified in our laboratory based on the expression patterns of the transcription factors TCF21 and SLUG (Varankar. S. et al. Carcinogenesis. 2019), were subjected to 48 hours of serum starvation (SS) or maintained in normal serum-fed conditions (+S) 24 hours post-seeding in triplicate. Following the treatment conditions, samples were harvested and analyzed using Orbitrap mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-10-08
AnnouncementXML	Submission_2025-10-08_08:48:06.385.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aravindan Narayanan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-13 12:39:13	ID requested
⏵ 1	2025-10-08 08:48:07	announced

Narayanan A, Guha S, Mali A, Bapat SA, Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells. Cell Death Dis, 16(1):676(2025) [pubmed]

10.1038/s41419-025-07987-1;

submitter keyword: Serum starvation, A4, CaOV3, ovarian cancer, OVCAR3,High Grade Serous Ovarian Carcinoma (HGSOC), OVCA420, OVMZ6

Sharmila A.
contact affiliation	BRIC-National Centre for Cell Science, Inside Pune Univesrity, Ganeshkhind, Pune, India, 411007
contact email	sabapat@nccs.res.in
lab head
Aravindan Narayanan
contact affiliation	BRIC-National Centre for Cell Science
contact email	aravindan@nccs.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD062888

PRIDE project URI

• PRIDE
  1. PXD062888
     1. Label: PRIDE project
     2. Name: Orbitrap proteomic analysis of five distinct molecular subtypes of High Grade Serous Ovarian Carcinoma (HGSOC) under serum deprived and serum fed conditions