PXD062861

PXD062861 is an original dataset announced via ProteomeXchange.

Title	Early proteomic response in thyroid gland after I-131 administration in female Balb/c mice
Description	131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I, and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.
HostingRepository	PRIDE
AnnounceDate	2025-09-08
AnnouncementXML	Submission_2025-09-07_16:27:17.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes Fuchs
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-11 10:32:42	ID requested
⏵ 1	2025-09-07 16:27:18	announced

Rudqvist N, Spetz J, Sch, ü, ler E, Parris TZ, Langen B, Wallem CS, Helou K, Forssell-Aronsson E, Early proteomic response in thyroid gland after 131I administration in female Balb/c mice. Radiat Prot Dosimetry, 201(13-14):887-898(2025) [pubmed]

10.1093/rpd/ncaf057;

submitter keyword: radiation biology

thyroid gland

radionuclide therapy

mass spectrometry

biomarker

Johan Spetz
contact affiliation	Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sweden
contact email	johan.spetz@gu.se
lab head
Johannes Fuchs
contact affiliation	Gothenburg University
contact email	johannes.fuchs@gu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD062861

PRIDE project URI

• PRIDE
  1. PXD062861
     1. Label: PRIDE project
     2. Name: Early proteomic response in thyroid gland after I-131 administration in female Balb/c mice