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PXD062777

PXD062777 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStructure-based design of potent and selective inhibitors of the HECT ligase NEDD4
DescriptionIn this study, we elucidated the mode of action of a class of drugs as NEDD4 inhibitors. These first-in-class NEDD4 inhibitors demonstrated exceptional specificity and selectivity, leaving the other family members unaffected.
HostingRepositoryPRIDE
AnnounceDate2025-05-29
AnnouncementXMLSubmission_2025-05-28_22:28:09.753.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterElena Maspero
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-09 02:07:29ID requested
12025-05-28 22:28:10announced
Publication List
10.1038/S42004-025-01557-4;
Keyword List
submitter keyword: ubiquitin
HECT E3 ligases
structure-based drug design
Contact List
Simona Polo
contact affiliationIFOM-ETS the AIRC Institute of Molecular Oncology
contact emailsimona.polo@ifom.eu
lab head
Elena Maspero
contact affiliationIFOM ETS - The AIRC Institute of Molecular Oncology
contact emailelena.maspero@ifom.eu
dataset submitter
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Dataset FTP location
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