PXD062777 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4 |
Description | In this study, we elucidated the mode of action of a class of drugs as NEDD4 inhibitors. These first-in-class NEDD4 inhibitors demonstrated exceptional specificity and selectivity, leaving the other family members unaffected. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-29 |
AnnouncementXML | Submission_2025-05-28_22:28:09.753.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Elena Maspero |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-04-09 02:07:29 | ID requested | |
⏵ 1 | 2025-05-28 22:28:10 | announced | |
Publication List
Keyword List
submitter keyword: ubiquitin |
HECT E3 ligases |
structure-based drug design |
Contact List
Simona Polo |
contact affiliation | IFOM-ETS the AIRC Institute of Molecular Oncology |
contact email | simona.polo@ifom.eu |
lab head | |
Elena Maspero |
contact affiliation | IFOM ETS - The AIRC Institute of Molecular Oncology |
contact email | elena.maspero@ifom.eu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062777
- Label: PRIDE project
- Name: Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4