PXD062777

PXD062777 is an original dataset announced via ProteomeXchange.

Title	Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4
Description	In this study, we elucidated the mode of action of a class of drugs as NEDD4 inhibitors. These first-in-class NEDD4 inhibitors demonstrated exceptional specificity and selectivity, leaving the other family members unaffected.
HostingRepository	PRIDE
AnnounceDate	2025-05-29
AnnouncementXML	Submission_2025-05-28_22:28:09.753.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elena Maspero
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-09 02:07:29	ID requested
⏵ 1	2025-05-28 22:28:10	announced

10.1038/S42004-025-01557-4;

submitter keyword: ubiquitin

HECT E3 ligases

structure-based drug design

Simona Polo
contact affiliation	IFOM-ETS the AIRC Institute of Molecular Oncology
contact email	simona.polo@ifom.eu
lab head
Elena Maspero
contact affiliation	IFOM ETS - The AIRC Institute of Molecular Oncology
contact email	elena.maspero@ifom.eu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062777

PRIDE project URI

• PRIDE
  1. PXD062777
     1. Label: PRIDE project
     2. Name: Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4