PXD062767

PXD062767 is an original dataset announced via ProteomeXchange.

Title	Deciphering Multi-Organ Protein Regulatory Strategies in Pelophylax nigromaculatus During Hibernation to Elucidate Energy Homeostasis Maintenance Mechanisms
Description	Hibernation, a natural physiological state characterized by reduced energy expenditure, represents a survival strategy adopted by organisms to endure adverse environmental conditions such as low temperatures and food scarcity. Amphibians frequently endure harsh hibernation conditions characterized by low temperatures and hypoxia, yet they typically exhibit rapid physiological recovery upon arousal without sustaining permanent organ or tissue damage. These remarkable capabilities stem from specialized organ-protective mechanisms and adaptive physiological regulation unique to hibernating species. This study employed Data-Independent Acquisition (DIA) quantitative proteomics technology to conduct comprehensive quantitative proteomic and phosphoproteomic analyses of the kidneys, liver, and lungs in Pelophylax nigromaculatus during hibernation, followed by multi-dimensional analysis of the protein regulatory strategies. Our multidimensional analytical approach elucidated intricate protein regulatory strategies underlying this hypometabolic state. The findings provide substantial and reliable datasets for advancing molecular investigations into hibernation mechanisms in amphibians, while establishing a foundational framework for understanding the molecular regulation of low-energy metabolism in animals.
HostingRepository	iProX
AnnounceDate	2025-04-09
AnnouncementXML	Submission_2025-04-08_23:50:14.066.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ningmei Wang
SpeciesList	scientific name: Pelophylax nigromaculatus; NCBI TaxID: 8409;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-08 23:49:38	ID requested
⏵ 1	2025-04-08 23:50:14	announced

Dataset with its publication pending

submitter keyword: Hibernation, Protein regulation, Pelophylax nigromaculatus, Proteomic

Hui Wang
contact affiliation	Hebei Normal University
contact email	whui1981@163.com
lab head
Ningmei Wang
contact affiliation	Hebei Normal University
contact email	767247571@qq.com
dataset submitter

iProX dataset URI