PXD062767
PXD062767 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deciphering Multi-Organ Protein Regulatory Strategies in Pelophylax nigromaculatus During Hibernation to Elucidate Energy Homeostasis Maintenance Mechanisms |
Description | Hibernation, a natural physiological state characterized by reduced energy expenditure, represents a survival strategy adopted by organisms to endure adverse environmental conditions such as low temperatures and food scarcity. Amphibians frequently endure harsh hibernation conditions characterized by low temperatures and hypoxia, yet they typically exhibit rapid physiological recovery upon arousal without sustaining permanent organ or tissue damage. These remarkable capabilities stem from specialized organ-protective mechanisms and adaptive physiological regulation unique to hibernating species. This study employed Data-Independent Acquisition (DIA) quantitative proteomics technology to conduct comprehensive quantitative proteomic and phosphoproteomic analyses of the kidneys, liver, and lungs in Pelophylax nigromaculatus during hibernation, followed by multi-dimensional analysis of the protein regulatory strategies. Our multidimensional analytical approach elucidated intricate protein regulatory strategies underlying this hypometabolic state. The findings provide substantial and reliable datasets for advancing molecular investigations into hibernation mechanisms in amphibians, while establishing a foundational framework for understanding the molecular regulation of low-energy metabolism in animals. |
HostingRepository | iProX |
AnnounceDate | 2025-04-09 |
AnnouncementXML | Submission_2025-04-08_23:50:14.066.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ningmei Wang |
SpeciesList | scientific name: Pelophylax nigromaculatus; NCBI TaxID: 8409; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-04-08 23:49:38 | ID requested | |
⏵ 1 | 2025-04-08 23:50:14 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Hibernation, Protein regulation, Pelophylax nigromaculatus, Proteomic |
Contact List
Hui Wang | |
---|---|
contact affiliation | Hebei Normal University |
contact email | whui1981@163.com |
lab head | |
Ningmei Wang | |
contact affiliation | Hebei Normal University |
contact email | 767247571@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |