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PXD062767

PXD062767 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDeciphering Multi-Organ Protein Regulatory Strategies in Pelophylax nigromaculatus During Hibernation to Elucidate Energy Homeostasis Maintenance Mechanisms
DescriptionHibernation, a natural physiological state characterized by reduced energy expenditure, represents a survival strategy adopted by organisms to endure adverse environmental conditions such as low temperatures and food scarcity. Amphibians frequently endure harsh hibernation conditions characterized by low temperatures and hypoxia, yet they typically exhibit rapid physiological recovery upon arousal without sustaining permanent organ or tissue damage. These remarkable capabilities stem from specialized organ-protective mechanisms and adaptive physiological regulation unique to hibernating species. This study employed Data-Independent Acquisition (DIA) quantitative proteomics technology to conduct comprehensive quantitative proteomic and phosphoproteomic analyses of the kidneys, liver, and lungs in Pelophylax nigromaculatus during hibernation, followed by multi-dimensional analysis of the protein regulatory strategies. Our multidimensional analytical approach elucidated intricate protein regulatory strategies underlying this hypometabolic state. The findings provide substantial and reliable datasets for advancing molecular investigations into hibernation mechanisms in amphibians, while establishing a foundational framework for understanding the molecular regulation of low-energy metabolism in animals.
HostingRepositoryiProX
AnnounceDate2025-04-09
AnnouncementXMLSubmission_2025-04-08_23:50:14.066.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNingmei Wang
SpeciesList scientific name: Pelophylax nigromaculatus; NCBI TaxID: 8409;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-08 23:49:38ID requested
12025-04-08 23:50:14announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Hibernation, Protein regulation, Pelophylax nigromaculatus, Proteomic
Contact List
Hui Wang
contact affiliationHebei Normal University
contact emailwhui1981@163.com
lab head
Ningmei Wang
contact affiliationHebei Normal University
contact email767247571@qq.com
dataset submitter
Full Dataset Link List
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