PXD062753
PXD062753 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein |
Description | O-GlcNAcylation is a dynamic and reversible post-translational modification involving the attachment of a single β-N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues. This modification occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins in mammalian cells and plays critical roles in regulating protein function, localization, and interactions. However, despite its widespread occurrence in host proteins, relatively few examples of O-GlcNAcylation have been reported in viral proteins. In this study, we sought to investigate the presence and functional relevance of O-GlcNAcylation in the vaccinia virus (VACV), a model poxvirus with a well-characterized replication cycle and virion architecture. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-27 |
AnnouncementXML | Submission_2025-05-27_06:19:47.067.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD062753 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Yunliang Zhang |
SpeciesList | scientific name: Vaccinia virus WR; NCBI TaxID: 10254; |
ModificationList | glycosylated residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-04-08 18:53:16 | ID requested | |
1 | 2025-05-20 16:34:31 | announced | |
⏵ 2 | 2025-05-27 06:19:47 | announced | 2025-05-27: Updated project metadata. |
Publication List
Zhang Y, Moss B, Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein. J Virol, ():e0005825(2025) [pubmed] |
10.6019/PXD062753; |
10.1128/jvi.00058-25; |
Keyword List
submitter keyword: A4, O-GlcNAcylation,Orthopoxvirus, O-GlcNAc |
Contact List
Bernard Moss | |
---|---|
contact affiliation | Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States |
contact email | bmoss@niaid.nih.gov |
lab head | |
Yunliang Zhang | |
contact affiliation | Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health |
contact email | zhangy58@nih.gov |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062753 |
PRIDE project URI |
Repository Record List
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