⮝ Full datasets listing

PXD062753

PXD062753 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein
DescriptionO-GlcNAcylation is a dynamic and reversible post-translational modification involving the attachment of a single β-N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues. This modification occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins in mammalian cells and plays critical roles in regulating protein function, localization, and interactions. However, despite its widespread occurrence in host proteins, relatively few examples of O-GlcNAcylation have been reported in viral proteins. In this study, we sought to investigate the presence and functional relevance of O-GlcNAcylation in the vaccinia virus (VACV), a model poxvirus with a well-characterized replication cycle and virion architecture.
HostingRepositoryPRIDE
AnnounceDate2025-05-27
AnnouncementXMLSubmission_2025-05-27_06:19:47.067.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD062753
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterYunliang Zhang
SpeciesList scientific name: Vaccinia virus WR; NCBI TaxID: 10254;
ModificationListglycosylated residue
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-08 18:53:16ID requested
12025-05-20 16:34:31announced
22025-05-27 06:19:47announced2025-05-27: Updated project metadata.
Publication List
Zhang Y, Moss B, Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein. J Virol, ():e0005825(2025) [pubmed]
10.6019/PXD062753;
10.1128/jvi.00058-25;
Keyword List
submitter keyword: A4, O-GlcNAcylation,Orthopoxvirus, O-GlcNAc
Contact List
Bernard Moss
contact affiliationLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States
contact emailbmoss@niaid.nih.gov
lab head
Yunliang Zhang
contact affiliationLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
contact emailzhangy58@nih.gov
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062753
PRIDE project URI
Repository Record List
[ + ]