PXD062753

PXD062753 is an original dataset announced via ProteomeXchange.

Title	Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein
Description	O-GlcNAcylation is a dynamic and reversible post-translational modification involving the attachment of a single β-N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues. This modification occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins in mammalian cells and plays critical roles in regulating protein function, localization, and interactions. However, despite its widespread occurrence in host proteins, relatively few examples of O-GlcNAcylation have been reported in viral proteins. In this study, we sought to investigate the presence and functional relevance of O-GlcNAcylation in the vaccinia virus (VACV), a model poxvirus with a well-characterized replication cycle and virion architecture.
HostingRepository	PRIDE
AnnounceDate	2025-05-27
AnnouncementXML	Submission_2025-05-27_06:19:47.067.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD062753
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yunliang Zhang
SpeciesList	scientific name: Vaccinia virus WR; NCBI TaxID: 10254;
ModificationList	glycosylated residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-08 18:53:16	ID requested
1	2025-05-20 16:34:31	announced
⏵ 2	2025-05-27 06:19:47	announced	2025-05-27: Updated project metadata.

Zhang Y, Moss B, Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein. J Virol, ():e0005825(2025) [pubmed]

10.6019/PXD062753;

10.1128/jvi.00058-25;

submitter keyword: A4, O-GlcNAcylation,Orthopoxvirus, O-GlcNAc

Bernard Moss
contact affiliation	Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States
contact email	bmoss@niaid.nih.gov
lab head
Yunliang Zhang
contact affiliation	Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
contact email	zhangy58@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062753

PRIDE project URI

• PRIDE
  1. PXD062753
     1. Label: PRIDE project
     2. Name: Identification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein