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PXD062745

PXD062745 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe source of dietary fat influences the immune response to syngeneic tumours in obesity – NK cell proteomic data
DescriptionObesity is linked to an increased risk of many cancers and can impair the anti-tumour immune response. This project examined the effect of different sources of dietary fats on tumour immunity using a syngeneic model of melanoma in mice fed high fat diets (HFD) derived from different sources. HFD based on beef tallow, lard and butter increased tumour growth in this model, while HFD derived from coconut oil, palm oil or olive oil did not. Further experiments focusing on butter and palm oil based HFD found differential regulation of natural killer (NK) cells and CD8 T-cell infiltration and function in the tumour microenvironment, and identified enrichment in immunosuppressive long chain acylcarnitine species in mice fed a HFD based on butter compared to palm oil. This dataset contains proteomic data from NK cells from mice fed a standard fat diet (SFD), NK cells from mice fed a HFD based on butter and from mice fed a HFD based on palm oil.
HostingRepositoryPRIDE
AnnounceDate2025-06-03
AnnouncementXMLSubmission_2025-06-03_08:31:27.778.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristina Rollings
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentExactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-08 10:16:28ID requested
12025-06-03 08:31:28announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: metabolism,NK cells, diet, anti-tumour immunity
Contact List
Lydia Lynch
contact affiliationDepartment of Molecular Biology, Princeton University, US
contact emailll6483@princeton.edu
lab head
Christina Rollings
contact affiliationUniversity of Dundee
contact emailcrollings@dundee.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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