PXD062706

PXD062706 is an original dataset announced via ProteomeXchange.

Title	Peritoneal Dialysis in Neuropsychiatric Systemic Lupus Erythematosus: A Case Report Integrating Proteomic Insights into Complement-Mediated Mechanisms
Description	Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE), characterized by heterogeneous neurological manifestations. Current therapies, such as plasma exchange (PE), are limited by cardiovascular risks and resource availability. This case report explores peritoneal dialysis (PD) as a novel dual-purpose therapy for NPSLE, combining renal support with immunomodulation. Case Presentation: A 42-year-old female with SLE presented with recurrent lower limb edema and dyspnea for 1 year, worsening over 2 weeks, followed by seizures. PD initiation alongside immunosuppressive therapy resolved neuropsychiatric symptoms and stabilized cardiorenal function. Proteomic Findings: PD fluid analysis showed significant down-regulation of complement-related proteins (FCER2 and CRP) on the fourth day after initiation of PD, suggesting PD attenuates neuroinflammation by targeted clearance of proinflammatory mediators. Conclusion: PD may serve as a viable adjunct therapy for NPSLE through modulation of complement overactivation.
HostingRepository	iProX
AnnounceDate	2025-04-08
AnnouncementXML	Submission_2025-04-08_00:15:31.749.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qinyuan Deng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-08 00:15:15	ID requested
⏵ 1	2025-04-08 00:15:32	announced

Dataset with its publication pending

submitter keyword: Systemic lupus erythematosus, Neuropsychiatric lupus, Peritoneal dialysis, Complement system, Proteomics

Qinyuan Deng
contact affiliation	Department of Nephrology, the First People’s Hospital of Yunnan Province
contact email	deng835552032@gmail.com
lab head
Qinyuan Deng
contact affiliation	Department of Nephrology, the First People’s Hospital of Yunnan Province
contact email	deng835552032@gmail.com
dataset submitter

iProX dataset URI