PXD062686

PXD062686 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomic profiling of neonatal rat ventricular cardiomyocytes (NRVCMs) following TRIM24 downregulation
Description	TRIM24 (Tripartite Motif-Containing 24) is a key transcriptional co-regulator involved in various cellular processes, including chromatin remodeling and gene expression. However, its role in cardiomyocytes remains largely unexplored. In this study, we investigated the global proteomic changes associated with TRIM24 downregulation in neonatal rat ventricular cardiomyocytes (NRVCMs) to better understand its function in cardiac biology. NRVCMs were transduced by an Adenovirus with a synthetic microRNA targeting TRIM24. Protein isolated from the NRVCMs transduced with a scrambled microRNA was used as control.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:36:15.205.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elke Hammer
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-07 09:02:09	ID requested
⏵ 1	2025-07-13 16:36:16	announced

Neu M, Deshpande A, Borlepawar A, Hammer E, Alameldeen A, V, ö, cking P, Seeger T, Hausmann M, Frey N, Rangrez AY, TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes. Cell Commun Signal, 23(1):312(2025) [pubmed]

10.1186/s12964-025-02323-8;

submitter keyword: TRIM24,rat, neonatal rat ventricular cardiomyocytes, LC-MS/MS

Elke Hammer
contact affiliation	Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald Germany
contact email	hammer@uni-greifswald.de
lab head
Elke Hammer
contact affiliation	Dept. of Functional Genomics
contact email	hammer@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD062686

PRIDE project URI

• PRIDE
  1. PXD062686
     1. Label: PRIDE project
     2. Name: Comparative proteomic profiling of neonatal rat ventricular cardiomyocytes (NRVCMs) following TRIM24 downregulation