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PXD062668

PXD062668 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrated Plasma and Vegetation Proteomic Characterization of Infective Endocarditis for Early Diagnosis and Treatment
DescriptionInfective endocarditis, a life-threatening condition, poses significant challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we analyzed plasma and vegetation proteomes from 238 patients with infective endocarditis and 100 controls, with two external validation cohorts. We developed machine learning-based diagnostic and prognostic models for infective endocarditis, with area under the curve values of 0.98 and 0.87, respectively. Leucine-rich alpha-2-glycoprotein 1 and NADH:ubiquinone oxidoreductase subunit B4 are potential biomarkers associated with infection severity. Pathologically, protein networks characterized by glycometabolism, amino acid metabolism, and adhesion are linked to adverse events. Liver dysfunction may exacerbate the condition in patients with severe heart failure. Neutrophil extracellular traps emerge as promising therapeutic targets in Streptococcus or Staphylococcus aureus infections. Collectively, our findings provide significant insights into biomarker discovery and underlying pathophysiological mechanisms in infective endocarditis, advancing early diagnosis and personalized medicine.
HostingRepositoryiProX
AnnounceDate2025-04-06
AnnouncementXMLSubmission_2025-06-04_00:14:56.382.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShiman He
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X; Orbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-04-07 00:26:07ID requested
12025-04-07 00:27:23announced
22025-06-04 00:14:57announced2025-06-04: Add Publication.
Publication List
He S, Hu X, Zhu J, Wang W, Ma C, Ran P, Chen O, Chen F, Qing H, Ma J, Zeng D, Wang Y, Liu W, Feng J, Gan L, Qin Z, Tan S, Tian S, Ding C, Jian X, Gu B, Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment. Nat Commun, 16(1):5052(2025) [pubmed]
Keyword List
submitter keyword: IE, Proteomics, LRG1, NETs, NYHA, Streptococcus
Contact List
Chen Ding
contact affiliationFudan University
contact emailchend@fudan.edu.cn
lab head
Shiman He
contact affiliationFudan University
contact email21112030018@m.fudan.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI