⮝ Full datasets listing
PXD062652
PXD062652 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of Cisplatin-Resistant and Sensitive MDA-MB-231 Triple-Negative Breast Cancer Cell Lines |
| Description | This dataset includes mass spectrometry-based proteomic profiles of cisplatin-resistant (cisR) and cisplatin-sensitive (cisS) MDA-MB-231 triple-negative breast cancer (TNBC) cell lines. The study aimed to investigate the molecular alterations contributing to cisplatin resistance using data-independent acquisition (DIA) proteomics. Key findings revealed upregulation of extracellular matrix (ECM) remodeling proteins (e.g., COL6A1, COL6A3), drug efflux transporters (e.g., ABCC4), and membrane-associated resistance proteins (e.g., TIMP1, MMP-14, APP), highlighting their potential roles in chemoresistance. The data provide insights into resistance-associated signaling, metabolic pathways, and potential therapeutic targets in TNBC. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-04-07 |
| AnnouncementXML | Submission_2026-04-06_08:00:05.181.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shashwati |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-06 23:30:30 | ID requested | |
| ⏵ 1 | 2026-04-06 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cisplatin resistance, TNBC, MDA-MB-231, proteomics, mass spectrometry, drug resistance, ECM remodeling, lipid metabolism, EMT |
Contact List
| Prof. Sanjeeva Srivastava | |
|---|---|
| lab head | |
| Shashwati | |
| contact affiliation | IIT Bombay |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003748/ |
