PXD062618 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling Of Bladder Cancer Patients-Derived Extracellular Vesicles |
| Description | Extracellular vesicle (EV) proteomics holds great promise for non-invasive cancer biomarker discovery. This study presents the first comprehensive proteomic characterization of EVs from tissue, plasma, and urine, focusing on bladder cancer BlCa. EVs were isolated via ultracentrifugation, and their cargo was analyzed, comparing BlCa patients to controls and patients with clear cell renal cell carcinoma (ccRCC) and prostate cancer (PCa), to identify BlCa-specific markers. Urine proved to be a rich source of BlCa EVs, enabling tissue-to-urine molecular tracking and insights into BlCa communication. Differential proteomic analysis revealed distinct BlCa EV profiles compared to healthy donors (HDs), ccRCC, and PCa. Importantly, we identified several candidate biomarkers, including ADAM8 and MMP12, exclusively present in BlCa tissue (50% and 64%, respectively) and urine EVs (83% each). Furthermore, six BlCa urinary EV proteins – ACKR1 (66%) and DHCR7, ERMAP, PTGS2, UBXN4, and GYPC (50% each) – were absent in HDs, ccRCC, and PCa. This study identifies several BlCa-derived EV proteins with strong potential for the development of non-invasive EV-based diagnostics and monitoring strategies for BlCa, potentially contributing to advancing precision medicine approaches for this malignancy . |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_18:02:42.507.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hugo Osorio |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-04 09:40:06 | ID requested | |
| ⏵ 1 | 2026-06-07 18:02:43 | announced | |
Publication List
| Louren, ç, o C, Const, â, ncio V, Tavares NT, Monteiro-Reis S, Silva-Santos R, Lobo J, Carvalho Â, Jer, ó, nimo C, From cell lines to the clinic: identifying a urinary BlCa-EV signature through comparative proteomics of bladder cancer lysates and extracellular vesicles. Cell Commun Signal, 24(1):(2026) [pubmed] |
| 10.1186/s12964-026-02868-2; |
Keyword List
| submitter keyword: Extracellular vesicles |
| Proteomics |
| Liquid biopsy |
| Biomarker |
| Bladder cancer |
Contact List
| Carmen Jerónimo |
|---|
| contact affiliation | Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP), Portuguese Oncology Institute of Porto, Porto, Portugal |
| contact email | carmenjeronimo@ipoporto.min-saude.pt |
| lab head | |
| Hugo Osorio |
|---|
| contact affiliation | i3S - Institute for Research and Innovation in Health, University of Porto |
| contact email | hosorio@i3s.up.pt |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD062618 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062618
- Label: PRIDE project
- Name: Proteomic Profiling Of Bladder Cancer Patients-Derived Extracellular Vesicles
