PXD062610

PXD062610 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Spatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment in celiac disease
Description	Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. This signal, hallmarked by increased expression of MHC molecules, coincides with a markedly reduced expression of proteins associated with fatty acid metabolism. This dataset contains protoemics analysis of crypt comparment samples isolated by laser capture microdissection of tissue sections from FFPE duodenal gut biopsies from human subjects with and without celiac disease.
HostingRepository	PRIDE
AnnounceDate	2025-08-08
AnnouncementXML	Submission_2025-08-08_01:37:55.154.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jorunn Stamnaes
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-04 08:12:57	ID requested
⏵ 1	2025-08-08 01:37:55	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: intestine, spatial proteomics,human, celiac disease

submitter keyword: intestine, spatial proteomics,human, celiac disease

Contact List

Jorunn Stamnæs
contact affiliation	Proteomics Core Facility, University of Oslo and Oslo University Hospital
contact email	jorunn.stamnas@medisin.uio.no
lab head
Jorunn Stamnaes
contact affiliation	University of Oslo Rikshospitalet
contact email	jorunn.stamnas@medisin.uio.no
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD062610
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD062610

PRIDE project URI

Repository Record List

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