PXD062566

PXD062566 is an original dataset announced via ProteomeXchange.

Title	Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis
Description	Cystine-xCT transporter-Glutathione (GSH)-GPX4 axis is the canonical pathway to protect against ferroptosis. While not required for ferroptosis-inducing compounds (FINs) targeting GPX4, FINs targeting the xCT transporter require mitochondria and its lipid peroxidation to trigger ferroptosis. However, the mechanism leading to the distinct difference between these FINs is still unknown. Given that cysteine is also required for coenzyme A (CoA) biosynthesis, here, we showed that CoA supplementation specifically prevents ferroptosis induced by xCT inhibitors but not GPX4 inhibitors.
HostingRepository	PRIDE
AnnounceDate	2025-07-05
AnnouncementXML	Submission_2025-07-05_14:55:35.342.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Erik Soderblom
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-03 07:47:43	ID requested
⏵ 1	2025-07-05 14:55:35	announced

Dataset with its publication pending

submitter keyword: proteomics,CoA, TXNRD2

Jen-Tsan Ashley Chi
contact affiliation	Professor in Molecular Genetics and Microbiology Duke University School of Medicine Durham, NC
contact email	jentsan.chi@duke.edu
lab head
Erik Soderblom
contact affiliation	Duke University
contact email	es114@duke.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD062566

PRIDE project URI

• PRIDE
  1. PXD062566
     1. Label: PRIDE project
     2. Name: Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis