⮝ Full datasets listing
PXD062529
PXD062529 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pan-neurodegeneration proteomics reveals disease subtypes and altered molecular signatures in six neurodegenerative disorders |
| Description | Neurodegenerative diseases (NDs) pose clinical challenges due to their complexity and molecular heterogeneity, limiting effective diagnosis and treatment. Here, we present an unprecedented multi-layered proteomic atlas of over 2,000 human brain samples spanning controls and six major NDs, including Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal lobar degeneration (FTLD), vascular dementia (VAD), Parkinson's disease (PD), and progressive supranuclear palsy (PSP). The profiling includes the whole proteome, detergent-insoluble aggregation-enriched proteome, and post-translational modifications of phosphorylation and ubiquitination. The atlas reveals distinct intra-disease and inter-disease proteomic signatures. The intra-disease analysis uncovers distinct molecular subtypes and dysregulated pathways within each ND, such as three AD subtypes and four LBD subtypes, independent of known pathological classifications. Inter-disease analysis identifies shared alterations in neuroinflammation and synaptic dysfunction and disease-specific alterations in protein aggregation, response to unfolded proteins and activation of developmental signaling. This large-scale proteomics study provides critical insights into ND mechanisms and offers a unique resource for future research. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-10 |
| AnnouncementXML | Submission_2026-02-10_15:44:56.734.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | PanNDproject |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | TMTpro; Carbamidomethyl; Oxidation; TMT6plex; Phospho; ubiquitination signature dipeptidyl lysine |
| Instrument | Orbitrap Exploris 480; Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-02 08:53:24 | ID requested | |
| ⏵ 1 | 2026-02-10 15:44:57 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Neurodegenerative diseases (NDs), proteomics, proteome, mass spectrometry, protein aggregation, Abeta, amyloid, tau, TDP-43, alpha-synuclein, U1 snRNP, post-translational modifications (PTMs), phosphorylation, ubiquitination, Lewy body dementia (LBD), frontotemporal lobar degeneration (FTLD), vascular dementia (VAD), progressive supranuclear palsy (PSP), molecular subtypes, disease network, Parkinson (PD), Alzheimer (AD), DatasetType:Proteomics |
Contact List
| Junmin Peng | |
|---|---|
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | junmin.peng@stjude.org |
| lab head | |
| PanNDproject | |
| contact affiliation | St Jude Children's Hospital |
| contact email | hshresth@stjude.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097496/ |
