⮝ Full datasets listing

PXD062504

PXD062504 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Aging-Associated Pro-inflammatory Shifts in Protein Corona Impact Pharmacokinetics
Description	Here, we reveal that age-associated shifts in plasma composition remodel the protein corona of liposomes, leading to divergent biodistribution and immune responses. Using plasma from young (1-month), middle-aged (9-month), and aged (18-month) mice, we demonstrate that liposomes incubated in aged plasma acquire coronas enriched with immunoglobulins, particularly IgG. This age-dependent IgG enrichment enhances macrophage uptake via Fc receptor-mediated endocytosis and amplifies complement activation through the alternative pathway, triggering NF-κB signaling and a pro-inflammatory cascade marked by M1 macrophage polarization.
HostingRepository	iProX
AnnounceDate	2025-04-02
AnnouncementXML	Submission_2025-04-02_01:43:55.645.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lirun Zhou
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue; methylthiolated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-02 01:43:41	ID requested
⏵ 1	2025-04-02 01:43:56	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Lip_Aged_PC

Contact List

Jigang Wang
contact affiliation	Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
contact email	jgwang@icmm.ac.cn
lab head
Lirun Zhou
contact affiliation	Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
contact email	lirunzhou1997@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI